Dispensing Tank
Fermentation Equipment
Solution Preparation Tank
Product Technical Specification
Model: PRP Series
1. Product Overview
A solution preparation tank (also known as a batching tank, compounding tank, or formulation tank) is a critical piece of equipment in biopharmaceutical and chemical production, used for precisely weighing, dissolving, mixing, and compounding multiple raw materials according to formulation ratios into solutions or suspensions of required concentrations. Equipped with agitation, temperature control, pH adjustment, and CIP/SIP systems, it ensures uniformity, accuracy, and sterility of the preparation process. Widely used in culture media preparation, buffer preparation, bulk dilution, and excipient dissolution.
Key Features
- Precise preparation, concentration deviation ≤±1%
- Full aseptic design, SIP at 121°C/30min
- CIP online cleaning, reduced cross-contamination risk
- Precise temperature control ±0.5°C
- VFD agitation for different viscosities
- Online pH monitoring and auto-adjustment
- GMP/FDA compliant, 21 CFR Part 11 data logging
2. Working Principle
Preparation Process
Typical process: WFI/PW injection → start agitation → add raw materials per formulation → heat/cool to target temperature → dissolve/mix uniformly → adjust pH → volume adjustment → sampling → transfer to downstream equipment via sterile piping. Entire process under closed aseptic conditions.
Aseptic Preparation
Requires Grade A cleanroom environment. Vessel and piping SIP sterilized. Raw materials added via sterile filtration. Solutions transferred through closed piping to avoid exposure.
3. System Classification
By Application
1. Culture Media Prep Tank
2. Buffer Prep Tank
3. Feed Prep Tank
4. Dilution Tank
By Volume
1. Small (10–100L)
2. Medium (100–2000L)
3. Large (2000–20000L)
By Pressure
1. Atmospheric Tank
2. Pressure Tank (design ≤0.3MPa)
4. Detailed Technical Parameters
Basic Parameters
| Parameter | Specification |
|---|---|
| Model | PRP-50 / PRP-200 / PRP-500 / PRP-2000 / PRP-5000 / PRP-10000 |
| Working Volume | 30–8000 L |
| Working Pressure | Atmospheric / Design 0.3MPa |
| Working Temperature | 5–130°C |
| Agitation Speed | 20–300 rpm (VFD) |
| Heating Method | Steam jacket / Electric |
| pH Control Range | 2.0–12.0 |
Tank Parameters
| Model | Volume(L) | Speed(rpm) | Heating | Motor(kW) |
|---|---|---|---|---|
| PRP-50 | 35 | 20–300 | Electric | 0.37 |
| PRP-200 | 140 | 20–200 | Steam/Electric | 0.75 |
| PRP-500 | 350 | 20–150 | Steam jacket | 1.5 |
| PRP-2000 | 1400 | 15–120 | Steam jacket | 3.0 |
| PRP-5000 | 3500 | 10–100 | Steam jacket | 5.5 |
| PRP-10000 | 7000 | 8–80 | Steam jacket | 11 |
Dimensions
| Model | Diameter(mm) | Body Height(mm) | Total Height(mm) |
|---|---|---|---|
| PRP-50 | 400 | 500 | 1200 |
| PRP-200 | 600 | 800 | 1800 |
| PRP-500 | 900 | 1200 | 2500 |
| PRP-2000 | 1400 | 2000 | 4000 |
| PRP-5000 | 2000 | 2800 | 5500 |
| PRP-10000 | 2800 | 3500 | 7000 |
Material Properties
| Component | Material | Description |
|---|---|---|
| Vessel | SUS316L | Electropolished Ra≤0.4μm |
| Jacket | SUS304 | Full jacket |
| Agitator | SUS316L | Anchor/Blade/Ribbon |
| Seals | Silicone/EPDM | FDA certified |
5. Core Component Selection
Vessel
SUS316L, electropolished Ra≤0.4μm, no dead-leg. Manway, sight glass, CIP spray ball, thermometer, pH port, level indicator, feed/discharge ports, SIP connection. Sanitary clamp connections.
Agitation System
Anchor or blade impeller, VFD 20–300rpm. Selected by viscosity: blade for low, anchor/ribbon for high viscosity.
Temperature Control
Steam jacket heating, cooling water cooling, PID ±0.5°C. PT100 sensor.
pH Adjustment
Online pH electrode, automatic acid/base addition. Peristaltic/diaphragm pump, ±0.5% accuracy.
Control System
SIEMENS/AB PLC, 7–12 inch touchscreen HMI. Recipe management, 21 CFR Part 11.
6. Typical Application Fields
Culture Media
Microbial media, cell culture media, feed media preparation
Buffer Preparation
Chromatography buffer, dialysis buffer, elution buffer
Pharmaceutical
Bulk dilution, excipient dissolution, formulation
Food
Beverage compounding, dairy formulation, flavor preparation
7. Design Standards & Certifications
Compliant with the following standards
1. GMP
2. FDA 21 CFR Part 210/211
3. ASME BPE
4. ISO 9001/14001
5. CE
8. Custom Optional Configurations
| Option | Details |
|---|---|
| Volume | 50–10000L |
| Impeller | Anchor/Blade/Ribbon/Dispersion |
| Heating | Steam/Electric/Thermal oil |
| pH | Online + auto |
| Weighing | Load cell + auto volume |
| CIP/SIP | Optional |
| Sterile Filtration | 0.22μm filter integration |
| Control | Manual/PLC |
9. Warranty Terms
| Status | Warranty | Scope |
|---|---|---|
| New | 12 months | Vessel, agitation, temp control, control system |
| Refurbished | 6 months | Agitation, control system |
10. Packaging & Delivery
| Item | Packaging |
|---|---|
| Main Unit | Anti-rust, plastic film, wooden crate |
| Instruments | Shock-proof |
| Electrical | Moisture-proof |
| Documents | Waterproof |
Lead time: New 60–120 working days; Refurbished 30–60 working days.
11. Information Required for Inquiry
For accurate quotation, please provide:
Preparation type
Volume
Viscosity range
Temperature range
SIP required
pH control
Heating preference
Impeller type
Weighing system
CIP/SIP
Material
Control mode
Voltage/frequency
New/Refurbished
Delivery terms