Mixer
Solid Preparation
Pharmaceutical Mixer
Model: MXR Series
1. Product Overview
The pharmaceutical mixer is indispensable in solid dosage production, where it uniformly blends powders, granules, and excipients so that every component is evenly distributed in the finished product. Combining different agitation and tumbling actions, it keeps material contacting and dispersing in three dimensions for highly efficient blending. Because blend uniformity directly governs tablet content uniformity and capsule fill-weight variation, mixer performance is critical to the pharmaceutical process. These machines are widely used for powder and granule blending in the pharmaceutical, food, chemical, and cosmetics industries.
Key Features
- High mixing uniformity, CV≤3%, ensuring content uniformity
- Multiple mixing types available: V-type, 3D, ribbon, trough
- Fully enclosed structure, preventing cross-contamination and dust emission
- GMP compliant, CIP/SIP optional
- Variable frequency speed control, adaptable to different material characteristics
- Optional vacuum feeding for closed transfer
2. Working Principle
V-type Mixing
V-type Mixer: Uses an asymmetric V-shaped vessel; with each revolution the material is split and recombined twice, delivering high mixing efficiency. Suited to free-flowing powders, with a fill ratio of 30%–50%.
3D Motion Mixing
3D Mixer: The vessel performs complex translational, rotational, and rocking motions in three-dimensional space, so material flows and spreads in every direction with no dead zones. Uniformity surpasses that of V-type mixers, making it the choice for materials with large density differences or poor flowability. Fill ratio up to 60%–80%.
Ribbon Mixing
Ribbon Mixer: Counter-rotating inner and outer ribbons generate simultaneous axial and radial convection — the inner ribbon moves material one way while the outer ribbon moves it the other way, creating forced convection. Suited to cohesive powders, pastes, and blends with added liquids.
Trough Mixing
Trough Mixer: Paddle blades rotate in a U-shaped trough, tumbling the material into a uniform blend. Simple and easy to operate, it suits small-batch, multi-product work and can be fitted with an agitator and chopper for combined mixing and granulation.
3. System Classification
By Working Method
1. V-type Mixer
2. 3D Motion Mixer
3. Ribbon Mixer
4. Trough Mixer
By Equipment Type
1. Laboratory type (1–30L)
2. Pilot type (30–300L)
3. Production type (300–6000L)
By Application Field
1. Pharmaceutical Industry
2. Food Industry
3. Chemical Industry
4. Cosmetic Industry
5. Nutraceutical Industry
4. Detailed Technical Parameters
Basic Parameters
| Parameter | Specification |
|---|---|
| Model | MXR-V / MXR-3D / MXR-RB / MXR-TR |
| Working Volume | 10–6000 L |
| Loading Ratio | 30%–80% (varies by type) |
| Mixing Uniformity | CV≤3% |
| Mixing Time | 5–30 minutes |
| Speed | 5–30 rpm (V/3D); 10–100 rpm (Ribbon/Trough) |
| Power | 0.37–37 kW |
Specification Parameters
| Model | Volume(L) | Mixing Type | Speed(rpm) | Power(kW) | Weight(kg) |
|---|---|---|---|---|---|
| MXR-V100 | 30 | V-type tumbling | 15–25 | 0.75 | 200 |
| MXR-V300 | 100 | V-type tumbling | 12–20 | 1.5 | 450 |
| MXR-V1000 | 300 | V-type tumbling | 8–15 | 3.0 | 900 |
| MXR-V3000 | 1000 | V-type tumbling | 5–12 | 5.5 | 1800 |
| MXR-3D100 | 30 | 3D motion | 10–20 | 0.75 | 250 |
| MXR-3D300 | 100 | 3D motion | 8–15 | 1.5 | 500 |
| MXR-3D1000 | 300 | 3D motion | 5–12 | 3.0 | 1000 |
| MXR-RB300 | 200 | Ribbon stirring | 20–60 | 2.2 | 600 |
| MXR-RB1000 | 600 | Ribbon stirring | 15–40 | 5.5 | 1200 |
Dimensions
| Model | Length(mm) | Width(mm) | Height(mm) |
|---|---|---|---|
| MXR-V300 | 1400 | 1000 | 1200 |
| MXR-V1000 | 2000 | 1500 | 1800 |
| MXR-3D300 | 1300 | 1100 | 1300 |
| MXR-3D1000 | 1900 | 1600 | 1900 |
| MXR-RB300 | 1600 | 900 | 1300 |
| MXR-RB1000 | 2400 | 1200 | 1800 |
Material Properties
| Component | Material | Description |
|---|---|---|
| Vessel/Trough | SUS316L | Electropolished interior, Ra≤0.4μm |
| Paddle/Ribbon | SUS316L | Polished surface, uniform clearance |
| Housing | SUS304 | Enclosed, mirror polished |
| Seals | Silicone/PTFE | FDA certified, temp range -20–200℃ |
| Bearings | SKF/NSK | Dust-sealed type |
5. Core Component Selection
Mixing Vessel
SUS316L stainless steel, electropolished interior, Ra≤0.4μm, no material adhesion. V-type/3D vessel optional seamless spinning-formed design, no dead zones, easy to clean. Inlet/outlet equipped with quick-connect clamps for closed operation.
Drive System
VFD motor drive, adjustable speed for different mixing processes. SEW/NORD reducer, smooth operation, noise≤65dB. Fully sealed transmission, lubricant isolated from product zone.
Sealing System
Mechanical seal or gas seal at shaft, preventing dust emission and cross-contamination. Vacuum-type mixer equipped with special sealing for vacuum operation. FDA-certified silicone or PTFE seal materials.
Feed/Discharge System
Feed inlet with quick-connect butterfly valve or vacuum suction interface. Discharge with butterfly valve or rotary valve for closed operation. Optional in-line sampling port for process monitoring.
Control System
SIEMENS/AB PLC controller, 7–12 inch touchscreen HMI, supporting mixing time setting, speed adjustment, forward/reverse control, and alarm functions. Optional recipe management and data logging, 21 CFR Part 11 compliant.
6. Typical Application Fields
Pharmaceutical Mixing
API and excipient blending, pre-compression granule and lubricant mixing, pre-capsule filling granule mixing, pre-dry granulation powder pre-blending, rework product re-blending
Food Industry
Seasoning blending, flour additive mixing, instant beverage powder mixing, food coloring mixing
Chemical Industry
Catalyst mixing, pesticide powder blending, chemical raw material mixing
Cosmetic Industry
Foundation powder mixing, loose powder blending, cosmetic raw material mixing
Nutraceutical Industry
Vitamin powder mixing, mineral powder blending, protein powder mixing
7. Design Standards & Certifications
Complies with the following standards and certifications
1. GMP (Good Manufacturing Practice)
2. FDA 21 CFR Part 210/211
3. ISO 9001 / ISO 14001
4. CE Certification
5. GB/T 28669-2012 General Technical Requirements for Pharmaceutical Machinery
8. Custom Optional Configurations
| Option | Details |
|---|---|
| Mixing Type | V-type / 3D / Ribbon / Trough |
| Volume | 10/30/50/100/200/300/500/1000/2000/3000/6000L |
| Feed/Discharge | Manual butterfly valve / Pneumatic butterfly valve / Vacuum feeding |
| Material Upgrade | Full SUS316L / Hastelloy |
| Control Mode | Manual / Semi-auto / Full-auto PLC |
| CIP/SIP | CIP/SIP connection (optional) |
| In-line Sampling | Sampling port (optional) |
| Explosion-proof | Ex d IIB T4 (optional) |
| Forced Stirring | Paddle addition (V/3D optional) |
9. Warranty Terms
| Equipment Status | Warranty Period | Warranty Scope |
|---|---|---|
| New Equipment | 12 months | Vessel, drive system, sealing system, electrical components |
| Refurbished Equipment | 6 months | Drive system, sealing system, electrical components |
10. Packaging & Delivery
| Item | Packaging Method |
|---|---|
| Main Unit | Anti-rust treatment, plastic film wrapped, wooden crate secured |
| Drive System | Moisture-proof treated, individually packaged |
| Electrical Box | Moisture-proof treated, individually packaged |
| Accompanying Documents | Waterproof bag sealed |
Lead time: New equipment 60–90 working days; Refurbished equipment 30–45 working days.
11. Information Required for Inquiry
To receive an accurate quotation, please provide the following information:
Material name and characteristics (density, flowability, stickiness)
Number of mixing components and ratios
Required batch capacity (L or kg)
Mixing uniformity requirements
Mixing type preference
Material requirements (SUS304/SUS316L)
Feed/discharge method preference
Control mode preference
Local voltage and frequency
Explosion-proof requirements (if needed)
CIP/SIP requirements (if needed)
Equipment preference: New/Refurbished
Budget range and brand preference
Delivery terms and destination port