Vacuum Mixer
1. Product Overview
1.1 General Description
The vacuum mixer is a dedicated machine for mixing materials under vacuum, widely used in the pharmaceutical, food and chemical industries wherever strict requirements are placed on the mixing environment. Inside a sealed vessel the agitator blades blend the material while the vacuum system extracts air from the vessel, preventing oxidation, moisture absorption and the entrapment of bubbles. The vacuum mixer is particularly suitable for oxidation-prone materials, bubble-containing products and GMP environments that require dead-leg-free cleaning. The agitation system can be configured with anchor, paddle or helical-ribbon impellers to match the material viscosity, and the jacket accepts heating or cooling media for temperature control. The complete machine is designed to meet GMP and FDA requirements, and all product-contact parts can be cleaned and sterilized in place.
1.2 Key Features
- Vacuum operation prevents oxidation and moisture pickup
- Effective deaeration for dense, pore-free products
- Sealed vessel with no dust emission for a clean environment
- Precise jacket temperature control within ±1℃
- Multiple impeller options to suit different viscosities
- CIP/SIP clean-in-place and sterilize-in-place functions
- GMP/FDA compliant
- Fully automatic PLC control with traceable process parameters
1.3 Document Scope
This specification covers the design principle, performance parameters, system classification, selection of key components, application fields, design standards and certifications, custom optional configurations, warranty terms, packaging and delivery, and the information required for an inquiry. It serves as a comprehensive reference for procurement, model selection and technical exchange.
2. Working Principle
2.1 Vacuum Mixer Process Flow
Vacuum mixer process flow: charging → sealing → evacuation → mixing → temperature control → vacuum degassing → vacuum break → discharge → CIP cleaning. After charging, the vessel door is closed and the vacuum system extracts the air down to the set vacuum level (below -0.095MPa). Once the agitation system starts, the impeller blends the material under vacuum; with no air resistance, mixing is more uniform. The temperature control system holds the material at the set temperature via the jacket. After mixing is complete, vacuum is maintained for degassing, with the degassing time set according to the material characteristics. Finally the vacuum is slowly broken to atmospheric pressure and the discharge valve is opened.
3. System Classification
| | | | |
|---|
| Laboratory | ZKH-50 | 50L volume | R&D / lab trials | Bench-top design |
| Pilot | ZKH-100, ZKH-300 | 100-300L volume | Pilot production | Vertical with CIP |
| Production | ZKH-500, ZKH-1000 | 500-1000L volume | Regular production | Vertical, fully automatic |
| Large-scale | ZKH-2000 | 2000L volume | Large-scale production | Heavy-duty design |
4. Technical Parameters
4.1 Main Technical Parameters of the Vacuum Mixer
| ZKH-50 | ZKH-100 | ZKH-300 | ZKH-500 | ZKH-1000 | ZKH-2000 |
|---|
| Working volume(L) | 50 | 100 | 300 | 500 | 1000 | 2000 |
| Total volume(L) | 80 | 160 | 480 | 800 | 1600 | 3200 |
| Motor power(kW) | 3 | 5.5 | 11 | 15 | 22 | 37 |
| Agitator speed(rpm) | 0-100 | 0-80 | 0-60 | 0-50 | 0-40 | 0-30 |
| Ultimate vacuum(MPa) | -0.095 | -0.095 | -0.095 | -0.095 | -0.095 | -0.095 |
| Jacket pressure(MPa) | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| Impeller type | Anchor/Paddle | Anchor/Paddle | Anchor/Ribbon | Anchor/Ribbon | Ribbon | Ribbon |
| Seal type | Mechanical seal | Mechanical seal | Mechanical seal | Mechanical seal | Mechanical seal | Mechanical seal |
4.2 Dimensions and Weight
| | | | | |
|---|
| ZKH-50 | 800 | 700 | 1200 | 300 | 0.6 |
| ZKH-100 | 1000 | 800 | 1400 | 600 | 0.8 |
| ZKH-300 | 1300 | 1000 | 1600 | 1200 | 1.3 |
| ZKH-500 | 1600 | 1100 | 1800 | 2000 | 1.8 |
| ZKH-1000 | 2000 | 1300 | 2100 | 4000 | 2.6 |
| ZKH-2000 | 2500 | 1600 | 2400 | 7000 | 4.0 |
5. Applications
| | | |
|---|
| Pharmaceutical | Ointments / suppositories / herbal pastes | GMP compliant, bubble-free | Ointment base |
| Food | Chocolate / sauces | Oxidation protection and degassing | Chocolate slurry |
| Chemical | Silicone / resins | Vacuum degassing | Silicone rubber |
| Cosmetics | Creams / lotions | Fine and bubble-free texture | Face cream |
| Battery | Electrode slurry | Vacuum degassing | Lithium battery slurry |
| Electronics | Thermally conductive silicone | Dense and bubble-free | Thermal grease |
6. Core Component Selection
| | | |
|---|
| Agitator | Mixing the material | SS316L | Anchor / paddle / ribbon selection |
| Vessel | Holding the material | SS316L | Inner wall polished to Ra≤0.4μm |
| Vacuum system | Evacuation and degassing | Liquid-ring pump + condenser | Ultimate -0.095MPa |
| Mechanical seal | Shaft-end sealing | Double mechanical seal | With seal-fluid system |
| Jacket | Temperature control | SS304 | 0.3MPa steam or cooling water |
| Discharge valve | Discharge control | Sanitary ball / butterfly valve | Pneumatic / manual |
| CIP system | Cleaning in place | Spray ball + piping | 360° dead-leg-free cleaning |
| Control system | Coordinated operation | PLC + touch screen | Programmable data logging |
7. Design Standards and Certifications
| | | |
|---|
| GB/T standards | Design and manufacture | Fully compliant | Type test report |
| GMP (cGMP) | Design, manufacture, documentation | Fully compliant | GMP compliance certificate |
| ISO 9001:2015 | Quality management system | Certified | ISO 9001 certificate |
| CE | Machinery safety / EMC | Optional | CE Declaration of Conformity |
| FDA | Food-grade / pharmaceutical-grade | Optional | FDA compliance documentation |
8. Custom Optional Configurations
| | | | |
|---|
| 1 | Impeller type | Anchor / paddle / ribbon / combined | Anchor | Combined +1-2 weeks |
| 2 | Vacuum level | Standard / -0.095 / high vacuum -0.099 | -0.095 | High vacuum +2 weeks |
| 3 | Temperature control | Electric heating / steam / thermal oil | Electric heating | Thermal oil +2 weeks |
| 4 | CIP/SIP | None / CIP / CIP+SIP | CIP | SIP +2 weeks |
| 5 | Explosion protection | Standard / ExdIIBT4 | Standard | Ex-proof +2-3 weeks |
| 6 | Discharge method | Bottom valve / pneumatic butterfly valve / pump-out | Bottom valve | Pump-out +1 week |
9. Material Property Requirements
| | |
|---|
| Working temperature | -40~250℃ | Depends on seals and materials |
| Corrosivity | Mild to moderate | Strong corrosion requires 316L or lining |
| Ex-proof requirement | Selected per site area | Zone1 / Zone2 ratings |
10. Warranty Terms
| | | |
|---|
| Main equipment warranty | 12 months | All components included | 12 months from acceptance after commissioning |
| Extended warranty (optional) | 24 months | Same as standard warranty | Must be purchased at order placement |
| Wear parts warranty | 6 months | Seals, bearings, etc. | Normal wear excluded |
11. Packaging and Delivery
| |
|---|
| Standard delivery time | 6-10 weeks after order confirmation |
| Delivery with custom options | 10-16 weeks |
| Incoterms | FOB Shanghai / CIF / DAP |
| Packaging | Export wooden case |
| Shipping | Container or break-bulk vessel |
12. Information Required for Inquiry
| | |
|---|
| 1 | Material name and properties | Name / viscosity / corrosivity |
| 2 | Required working volume | L / batch |
| 3 | Vacuum requirement | MPa |
| 4 | Impeller preference | Anchor / paddle / ribbon |
| 5 | Temperature control requirements | Range / accuracy |
| 6 | CIP/SIP requirement | Yes / No |
| 7 | Material requirement | SS304/316L |
| 8 | Ex-proof requirement | Standard / Ex-proof |